Preformulation Studies of Varenicline for Formulation and Development of a Novel Orally Disintegrating Film

Objective: The major goal of pre-formulation research is to create a drug delivery system that stable, elegant, safe, and effective by determining the drug's kinetic profile, formulation's compatibility with various excipients, physico-chemical characteristics new molecules. This could offer crucial support for executing formulation design or need molecular change. Therefore, in current study, studies on Varenicline (VAR)'s appropriateness oral were conducted. Similar cytisine, VAR functions as partial nicotine receptor agonist. It blocks alpha-4-beta-2 nicotinic acetylcholine subtypes Through agonism, reduces urge withdrawal symptoms associated quitting efforts inhibiting dopaminergic activation brought smoking. stops from stimulating mesolimbic dopamine pathway, which linked addiction.
 Methods: authenticity was established DSC FTIR spectra. A UV spectrophotometric method employed determination bulk active pharmaceutical ingredient (API).
 Results: For API (active ingredient), approach used. In concentration range 5–40 g/ml, technique linear. lower% CV values intraday interday variability indicate proposed methodology's robustness. higher regression coefficient value(0.999) indicates methodology robust.
 Conclusions: outcome experiments molecule suitability route. Additionally, at different conditions like solid well liquid state, drugmoleculewasobservedstable.